According to Sportsbook Review, Jacksonville comes into Lucas Oil Stadium as 3 1/2 point favorites against a Colts team that is only one game behind them in the divisional standings.
Factoring in the usual 3 points for home field advantage, this point spread assumes that the Jaguars are approximately 6 1/2 points better than Indianapolis on a neutral field. However, Indianapolis will be working on a short week after playing on Monday Night Football, which could add a 1/2-point of value on Jacksonville.
The Colts have been much better at home this season as they’ve covered the spread in each of their three games at Lucas Oil Stadium, winning two of them outright.